منابع مشابه
Efficiency of carcinogenesis with and without a mutator mutation.
Carcinogenesis involves the acquisition of multiple genetic changes altering various cellular phenotypes. These changes occur within the fixed time period of a human lifespan, and mechanisms that accelerate this process are more likely to result in clinical cancers. Mutator mutations decrease genome stability and, hence, accelerate the accumulation of random mutations, including those in oncoge...
متن کاملGeneration of mutator mutants during carcinogenesis.
Mutations are rare in normal cells. In contrast, multiple mutations are characteristic in most tumors. Previously we proposed a "mutator phenotype" hypothesis to explain how pre-cancer cells may acquire large number of mutations during carcinogenesis. Here we extend the "mutator phenotype" hypothesis considering recently discovered biochemical activities whose aberrant expression may result in ...
متن کاملMutation accumulation and fitness in mutator subpopulations of Escherichia coli.
Bacterial populations in clinical and laboratory settings contain a significant proportion of mutants with elevated mutation rates (mutators). Mutators have a particular advantage when multiple beneficial mutations are needed for fitness, as in antibiotic resistance. Nevertheless, high mutation rates potentially lead to increasing numbers of deleterious mutations and subsequently to the decreas...
متن کاملMutator genes and selection for the mutation rate in bacteria.
Gene frequencies in populations of haploid, asexual organisms are described by linear recurrence equations. Several models in which the mutation rate is controlled by one locus and the fitness is controlled at one or more other loci are developed. It is shown that good approximations can be introduced to give explicit solutions for the course of selection in these models. It is shown that a str...
متن کاملNickel carcinogenesis, mutation, epigenetics, or selection.
ofcells to carcinogenic nickel compounds induces many genes that are commonly expressed in cancer cells but not in normal cells. Nickel compounds have been well established as human carcinogens. Investigations into the molecular mechanisms of nickel car-cinogenesis have revealed that not all nickel compounds are equally carcinogenic: certain water-insoluble nickel compounds exhibit potent carci...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1996
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.34.715